Dr. Charles and Dr. Reese search for answers when a mother brings in her daughter claiming she is possessed. Dr. Rhodes and Dr. Bekker are tasked with finding a way to save a pair of conjoined twins.
Chief Boden faces accusations that he abandoned a homeless man to die in a warehouse fire; Severide helps an elderly woman; Detective Voight tries to convince Casey not to testify against his son; Shay has to face her ex during a call.
Dr. Manning rushes to save a young boy who has a life threatening case of the flu. After discovering that opioid pain killers were stolen during last week's mass casualty, April believes Dr. Choi's sister took them.
Dr. Choi struggles to help a woman cope with anorexia. After a two week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles.
When a car unexpectedly smashes through the ambulance bay doors, Dr. Choi makes some difficult decisions in an effort to save a worker trapped beneath the wreckage and April, who's also in danger.