A guard dog who protects an 80-acre horse farm becomes best friend and guardian to a frail quarter horse. Then a golden retriever goes overboard with her dolphin friends in the Florida Keys.

A high-energy hound meets his match and finds the ideal playmate in a tiger cub named Thunder. In Oklahoma, a pit bull develops a tender bond with a 2-tonne steer.

9000 lbs do not prove to be too much to handle for an 80 lb black lab named Bella when she?s splashing around with her bestie, Bubbles, an African elephant.

A golden lab is a constant companion and calming force for the cheetahs at the Columbus zoo. Then, a playful puggle likes to snuggle with a rabbit named Purple.

A feisty daschund named Abby is the dearest friend of a Barbary lion named Bonedigger.

While most cats and dogs are at each other?s throats, Tink the 2-legged dachsund and Henry the 3-legged cat make for the perfect companions.