Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.

Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.

Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminescence.

Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.

Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-blooming San Pedro cactus as a medicine.

Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs to understand the process behind a great American folk art.

Hamilton traces the multi-billion year history of nitrous oxide on Earth and follows a strange noble gas to the Czech Republic.

After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

Succumbing to viewer requests, Hamilton journeys to Argentina to understand the legend of Anadenanthera, the world's oldest psychedelic.

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.