A team of investigators re-examines the O.J. Simpson case; they inspect a knife that could be the murder weapon, and sit down with family members Fred Goldman and Tanya Brown to get their personal insights.

After examining evidence both old and new, the team questions O.J.'s role in the crimes; Dr. Henry Lee, a forensics expert from the original investigation gives his insight.

Private investigator Bill Dear has collected evidence for the past 21 years suggesting a new possibility in the murders of Nicole Brown Simpson and Ron Goldman; the team takes a closer look at Dear's "person of interest".

Kris Mohandie and Derrick Levasseur raise questions about the validity of the potential person of interest's alibi from the night of the murders: was the truth being told, and if not, did this individual play a role in committing the crimes?

O.J. Simpson has claimed that "if" he committed the murders, he couldn't have done it alone; the team asks Kato Kaelin and others whether anyone else could've been involved, and a new potential eyewitness comes forward.

After coming forth with new information, a possible eyewitness takes a polygraph test; DNA results from a potential murder weapon are in; the team reveals what they believe really happened that night.