Angus "Mac" MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.

MacGyver and the team attempt to rescue Sarah, Jack’s former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.

MacGyver and the team are in Malaysia to extract a terrorist group’s money man, Ralph, who holds key intel on an impending attack. But the mission goes south when the man is shot, and now, with only a driver’s license and hand sanitizer available, MacGyver must keep Ralph alive in order to learn the terrorists’ plans.

Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow. But when the antiquated computer needed to disable the warhead becomes inoperable, Mac must find a way to fix it with only duct tape and wire in time to prevent a new Cold War.

Using only an armrest, a curtain rod, and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.

Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.