Most Extreme Humans

Mark's hands are 20 times bigger than a normal adult male's; after learning that his condition may require amputation, Mark stopped seeing doctors; now troubling changes to his hands means he must go back.

Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured; with 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

In Brazil, Claudio lives with a condition that bent his head backward; ahead of his 50th birthday, he wants to climb a sacred mountain; in Norway, Birgitte is training for the next Paralympics.

Life defined by height: in Turkey, the world's tallest woman lives with an unknown genetic condition linked to extreme growth and fragile bones, while in Brazil, the world's shortest couple navigate dwarfism and its physical challenges.