In classic Investigation Discovery style, "Murder in the Heartland" weaves harrowing narratives of quiet Middle America towns torn apart by provocative crimes. Each town's tale is given life by the combined perspectives of its residents, who are more than just storytellers. The interviewees were also key witnesses to each of the crimes, and they hold critical clues to puzzles that not only have forever changed their lives but how they have come to view their once-idyllic hometowns.