Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

The 4 best reasons for Coliesa to live are her daughters. But after a heart attack and losing the love of her life in a car crash, Coliesa eats non-stop to escape from reality, and unless she can stop that, the next heart attack will be fatal.

Dominic's life is falling apart due to his food addiction. At over 600-lbs, living in a van with his brother, Dominic decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan can't do much on her own. Now, Megan must travel to Houston to meet Dr. Now and change her eating habit or her life may end before it ever begins.

For 23 years, Leneatha has worked as a pharmacy tech at a local hospital. Now, she has a young daughter to support, but she's so big that it's hard to move. If Dr. Now can't help her stop eating, losing her job could be the least of her worries.

At nearly 1,000 pounds, Samantha is dangerously close to dying. To make matters worse, she's paid to eat by making videos online. If Samantha doesn't overcome her toxic relationship with food, she worries that she will leave her daughter motherless.

Thederick has become housebound from eating, and for 10 years, he's only gone outside to greet the ice cream man. After a recent hospital scare, it's finally clicked that if Dr. Now's program doesn't work for him, then nothing will.

20 years after her dad died as a result of a botched weight loss surgery, Carrie is on the brink of eating herself to death. To live, she must face the fear and grief of losing her father and end a cycle of toxic behaviour with her husband Chris.

Cindy is resistant to change and has spent years creating a world that makes her feel safe. When her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now. But Cindy isn't so easily persuaded.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body. Now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Kenae' was already big before her weight gain took off after the death of her beloved mother. Refusing to deal with the pain, Kenae' turned to food to fill the void. But she'll be reunited with her mom soon if the denial continues.