Plagued by health problems, Meghan hopes to get weight loss surgery along with her overweight best friend, Vannessa. Vannessa is afraid of trying to lose weight only to fail. When she sees Meghan successfully lose weight, however, she changes her mind.

Corey is a young gay man who is just getting back on his feet after being homeless; He has dreams of getting back into college and finding a serious relationship, but he needs to make huge changes if he is going to live his dreams.

George is a kind-hearted kindergarten teacher who weighs nearly 700 pounds. He is determined to lose weight to help him win back his ex-girlfriend. As George works hard to lose weight, he discovers that the love he has been missing most is self-love.

Jennifer used to do everything with her family, but a car accident five years ago led to severe weight gain and a massive lymphedema on her leg. Jennifer feels like bariatric surgery is her last chance to regain mobility and get her family life back.

Jasmin is a young single mom who weighs 604 pounds and has lost almost all of her independence. Her mother was recently diagnosed with MS, and Jasmin knows that she must get bariatric surgery so she can take care of her mom and her 7-year-old son.

At 708 pounds, Jessica is battling a host of life-threatening illnesses. Amanda, a former patient of Dr. Procter, convinces Jessica she must pursue bariatric surgery. Unfortunately, an emergency hospitalization throws Jessica's weight loss off track.