Jackson Oz, a young renegade American zoologist living in Africa, discovers a link between strange animal attacks on people occurring around the world and his late father's controversial theories about an impending threat to the human race. Meanwhile, journalist Jamie Campbell and veterinary pathologist Mitch Morgan team up to investigate similar abnormal animal behavior in Los Angeles.

When Jackson's best friend, Abraham, has a dangerous encounter with a lion, Abraham thinks lions might be killing humans for sport; Chloe tries to overcome her trauma and resume working as a government intelligence analyst in Paris.

Jackson wants go to Japan to recover the rest of his father's research on animals; Jamie invites Mitch on a trip to her hometown to present their findings on the zoo lions' abnormal behavior; Chloe is recruited by an intelligence agent.

The team travels to Mississippi to investigate the wolf attack on the prison; the team meets an agent who may have knowledge about the prison fire.

Agent Shaffer, Jamie and Jackson look for a chemist in Alabama who has evidence of Reiden Global's role in the animal problem; Chloe, Mitch and Abraham are faced with a ruthless drug lord in Rio de Janeiro.

Abraham must save Mitch and Chloe when they are abducted by a drug lord; the search for Evan Lee Hartley and the stolen evidence puts Jamie in trouble with the FBI.