S5, E1: In the fifth season premiere episode, Sheldon (IAIN ARMITAGE) and Missy both run away from home, while Mary (ZOE PERRY) gets some upsetting news about George Sr. (LANCE BARBER).

Starring Wallace Shawn, Melissa Peterman, Ava Allan
S5, E1: In the fifth season premiere episode, Sheldon (IAIN ARMITAGE) and Missy both run away from home, while Mary (ZOE PERRY) gets some upsetting news about George Sr. (LANCE BARBER).