Through Lexie, Meredith tries to get Derek interested in a patient's rare brain tumor; Callie ends up being annoyed when Mark and Arizona finally form a friendship; Teddy and Alex look into alternative surgeries for a superficial patient.
When a car careens out of control over an embankment, killing a middle-aged man in the driver’s seat, Megan learns that all is not well on a pretty suburban cul-de-sac.
Alexis asks Castle for help proving a death row inmate's innocence 72 hours before his execution, but they uncover a secret that could seal the man's fate.