Reynolds attempts to help a cystic fibrosis patient with some curious symptoms. Meanwhile, Kapoor and Ella finally meet again following their awkward encounter.

The doctors try to save an NYPD who was hit by a car while on the job. Meanwhile, Kapoor and Iggy care for a patient struggling with issues from a previous surgery.

As things become more and more difficult for him, Max is forced to face his diagnosis. Meanwhile, Reynolds begins to comprehend what could have gone wrong in a recent surgery.

Max confronts hospital administration, when he comes up with a plan for patients lacking insurance. Meanwhile, Iggy finds it hard to cope with accusations and Sharpe deals with her role as deputy medical director.

Sharpe comes up with a way to help Max, as Kapoor receives some surprising news and Reynolds takes the next step in his relationship with Evie.

Max works to find a new normal three months after the accident and the birth of his daughter; Kapoor grapples with the stigma of aging; Iggy has a successful day that inspires a life-changing idea; Reynolds deals with an unreliable new intern.

Max invokes a hospital-wide census in an effort to get to know the staff of New Amsterdam on a deeper level; Reynolds takes a leap of faith that lands him in hot water; Dr. Castro extends her treatment plan to more patients in the hospital.

Max takes a chance on a new assistant and goes toe-to-toe with the board on a new plan; Iggy struggles to figure out what is causing a unit-wide illness; Kapoor receives some shocking news.

When Iggy and Kapoor discover a patient might be suffering from lead poisoning, they are forced to take on the city; Max's unsolicited attempts to help a patient backfire.

When Sharpe has a case that hits close to home, she and Max team up to make things right for the patient; Iggy and Bloom are forced to make a tough call on a unique situation.

When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy; Sharpe and Kapoor work together to mend fences between two feuding sisters.