Interior Designer Thom Filicia and his bestie, Fashion Guru, Carson Kressley take on homeowners Sherrie & Dave, who want to turn their vast living room and grotto into a fun but functional family space. However, decorating becomes a challenge with a client who proves to be the most indecisive person in New York!  Meanwhile they have to navigate a unique scenario with their second client, Zenobia, a psychic living with the ghost of her dead mother-in-Law, Mrs. O'Connell, who has opinions of her own!

Thom and Carson are given a run for their money when they take on Kenyatta, a former interior designer, who has a problem letting go of control; client Scott, who has recently come out of the closet, wants to transform his studio apartment.

Thom and Carson must combine Joe's over-the-top Italian style with Lisa's modest taste, while adhering to the budget which is presented on a spreadsheet; Thom and Carson redesign Akim's bakery before the single mother re-launches her business.

Tasked with getting their home Shabbat ready, Thom and Carson help Sara and Ehud find balance between Sara's quirky aesthetic and Ehud's traditional taste; the duo helps Lucas, a trans man, who is looking to transform his basement into a home gym.

Thom and Carson work with soon-to-be empty nesters Laurie and Jeff, who are ready to turn their living room into a chic Vegas lounge; Brooklyn dentist Dr. Cox is troubled with bad online reviews due to her dismal waiting room.

Jessica and Josh hire Thom and Carson to design their Tribeca loft space, which has one big challenge the guys must design around; a widow wants a fresh start while honoring her husband in the home they shared together.