House must diagnose a young woman who survived a building collapse but is now suffering from a mysterious fever. Without the help of his old team, House is determined to cure the patient by himself - but a series of ever-more alarming symptoms suggests the case is not all that it seems.
In the powerful fourth season finale, the Tree Hill High School graduates share their bittersweet final moments together. At the same time, both Karen and Haley go into labor, while their loved ones stand by. Brooke has a surprising reunion with someone from her past. Peyton struggles with the thought of spending the summer away from her friends. Dan tries to assuage his guilt by making a life -changing decision. And, reflecting on the amazing journey that has brought them to the point of being true brothers, Nathan and Lucas seek closure regarding Dan.
As graduation day at Tree Hill finally arrives, Brooke's guilty conscience prompts her to make an important decision, while Haley prepares her valedictorian speech. Peyton accepts an internship in California. Karen experiences problems with her pregnancy. Unable to get a scholarship at any college due to his recent scandal, Nathan tries to define his future. And Lucas tells Deb the truth about what Dan did.
Lucas discovers who was in the hallway when his uncle was killed. Meanwhile, Peyton's decision not to attend the prom leads to dire consequences. Nathan and Haley vow to just be romantic teenagers at prom, while Dan tries to win Karen's affections, as the witness to his murder closes in.
Haley confronts Brooke regarding the stolen calculus test. Meanwhile, Lucas and Peyton consider taking their relationship to the next level. Peyton and Brooke grow closer. And, In Deb's absence, Nathan throws a senior party at the Scott house, where a sex tape from Nathan's past surfaces.
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