The team race against time to find a young girl who has gone missing from a mall in Virginia, believing her to be the next victim of a serial killer that murdered his previous victim within an hour of abduction.
Sun and Jin's lives are put in danger when Sayid tries to locate Jack and the other missing castaways. Sayid also creates a plan in order to get the attention of the `Others' on the beach.
Sawyer discovers just how far his captors will go to thwart any plans of escape he and Kate might have, and Jack is called upon to scrub up in order to save the life of one of "The Others." Meanwhile, Desmond's behavior begins to perplex the survivors when he starts construction on an unknown device.
Lightman is called to a psychiatric hospital to determine if a patient is being held against his will. Attempting to have the patient released, Lightman finds himself descending down a path that forces him to question his own sanity.
Luka gets some important news, and at the end of the day, an unexpected visitor. Meanwhile, a collision between a motorcycle and a car brings critical patients to the ER.
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