The BAU team begin to track a family in Alabama who are working together to abduct young women. The family travel from city to city leaving clues behind, but their route becomes increasingly difficult to follow.
A six-year-old girl is brought in suffering from symptoms more befitting an adult woman, House enjoys leading Wilson a merry dance when he meddles in his friend's love life, and Cameron and Chase consider where their relationship went wrong.
A man suffering from a brain aneurysm asks Melinda to help him find the ghost of his former girlfriend, who died in a boat accident a few years earlier.
Melinda assists Ned's girlfriend who thinks she is being haunted by her dead father.
In a bonus episode of the first season, Martin's car mysteriously breaks down in the town where he first became a reporter.