Addison doubts her abilities as a doctor, Cristina pushes Burke's rehabilitation, one of the interns suffers their own medical emergency, and Izzie receives the surprise of her life.
A waitress with a perfect memory suffers temporary paralysis. Things complicate further when her older sister visits her in hospital. Meanwhile, House discovers Wilson's secret new companion.
While the team investigate a series of random murders in northern Virginia, an unexpected arrival may hold a secret from Rossi's past.
Michael walks into a trap in his attempts to put T-Bag back in jail, Sara awaits her fate in court, and Kellerman decides to take drastic action.
Michael, Lincoln and Sara attempt to make contact with somebody who can be trusted with the recording, Mahone gives Bellick another job to do, and C-Note is faced with a terrible choice.