Patrick Jane and the team investigate the murder of a mayor's aide, and Rigsby and Van Pelt make a big announcement. NYPD Blue’s Sharon Lawrence guest stars as the Mayor.
A fireman is treated for suspected male menopause, before House's team realise that he has actually suffered a series of heart attacks. As they struggle to determine the cause, Cameron makes a surprising diagnosis. Meanwhile, House is forced into rehab as the case against him reaches court.
Sam packs up to head to California and launch his congressional campaign, Toby critiques Sam's campaign manager's speechwriting skills, and CJ duels with a reporter who's unhappy about his pressroom seat assignment.
After forming a partnership with a demon named Doyle, Angel rescues Cordelia from a powerful vampire who preys on luckless Hollywood starlets.
When a Russian bomber goes missing while flying over U.S. soil, Callen and Sam must track it down in the desert and secure its weapons and intel before the Russians on board destroy the plane; Hetty gives Nell a cryptic assignment.
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