When a beautiful woman (Jaimie Alexander) with no memory of who she is or how she got there is discovered naked in New York's Times Square, the conspicuous etching of FBI Agent Kurt Weller's (Sullivan Stapleton) name across her back quickly makes it obvious to whom the case should be assigned. An international plot blows up as Agent Weller and his team discover that each intricate tattoo on Jane Doe's body is a crime to solve, creating a map that leads ever closer to the truth about her identity and mysteries yet to be revealed.