With the arrival of new residents, in particular a young, handsome unmarried Doctor, the womenfolk of Cranford are sparkling with anticipation. But are they really ready for the changes that are about to descend upon them? Matty Jenkyns and her older, stricter sister Debora are particularly excited as a new house guest and neighbours arrive. When Jem, the local carpenter, falls from a tree, all eyes are upon on the new doctor and his untested modern methods.

A visitor to Cranford brings joy and hope to Jessie Brown. Meanwhile, Mr Carter oversees preparations for Lady Ludlow's garden party. It turns out to be a day that Cranford will never forget. Miss Matty is very shaken when she unexpectedly meets someone from her past. Shock and panic erupt after some eavesdropping unveils startling news which threatens to rip through the heart of Cranford and change it forever.

A theft from the Doctor's house and an attack on Mr Johnson spread panic and the fear of an imminent crime wave. Suspicion and mistrust ripple through Cranford and Miss Pole resorts to desperate measures to safeguard her treasures! To save his father, Harry is forced to make a formidable decision, thereby putting himself in danger. In these uncertain times, the ladies cluster together for Christmas.

A maze of misunderstandings leads the ladies of Cranford astray as May Day brings hopes of love into many hearts. Miss Tomkinson's ambiguous conversation with the young doctor sets in motion a disastrous train of events. Will he be able to survive the turmoil that results and secure the affections of the one he loves? Meanwhile, Miss Matty is forced to face up to some life-changing news. Will she be able to keep it a secret for long in Cranford?

Dr Harrison finds both his career and his reputation ruined, and his courtship destroyed. Miss Matty receives devastating news, but the true values of Cranford's friendships become apparent as the ladies secretly rally to help. Miss Galindo and Mr Carter's friendship strengthens as they are forced to face up to the true tragedy of Hanbury. But will Miss Galindo be able to help Mr Carter carry out his wishes? And who will be able to adapt to change?

Miss Matty becomes concerned about an isolated youngster as Mr Buxton returns to town. The shadow of the railway looms over Cranford.