Joseph "Run" Simmons, Darryl "DMC" McDaniels and Jason "Jam Master Jay" Mizell meet on the streets of Hollis, Queens, and form RUN DMC; the hip-hop legends release their first single, debuting their unique lyrical style and vocal chemistry.

RUN DMC defies critics and legitimizes a genre of music that was once labelled a fad; as their fame grows and the explosion of "Walk This Way" alienates their core fanbase, the group struggles to find a consistent voice.

As "Down With the King" tops the charts, the group embarks on their personal journeys and tragedies; Jay is tragically murdered, leading to the group's demise; years later, Rev and DMC reunite to celebrate their legacy.