James Nesbitt stars as brilliant neurosurgeon Gabriel Monroe in a new six-part medical drama series created by acclaimed writer Peter Bowker. At work, Monroe has the courage to perform cutting edge brain surgery - operating on the very thing that makes us who we are. At home, he is afraid to admit that his life is falling apart. Nobody is more aware of Monroe's flaws than Jenny Bremner, a glacial cardiac surgeon with little time for Monroe and his emotional approach to his patients. When Alison Bannister is admitted with a brain tumour, Monroe has to help her make a frightening decision. To go ahead with an operation could leave Alison paralysed or unable to speak, yet without surgery, she is likely to die within a few years. Does she want to survive if surgery might change who she is? And can Monroe get her through this crisis as his own life starts to spiral out of control?

New medical drama series. As Monroe struggles to accept the fact that his wife Anna has left him, he throws himself into work and tries to pretend that his life is not in free fall. Can he find the courage to tell his son the truth about why his marriage ended? At the hospital, Monroe and cardiac surgeon Jenny Bremner have to deal with a double shooting after a 14-year-old boy accidentally shoots his 12-year-old brother, before attempting to kill himself. Monroe's over-enthusiastic trainee Daniel Springer literally manages to add insult to injury by offending the boys' father as his son lies on the operating table, so Monroe resorts to unusual measures to prove that the boys are in good hands. Shepherd is buoyed up by a mystery date, but refuses to share any details with Monroe and hospital porter Lee Bradley.

Medical drama series. With his family home up for sale and his teenage son Nick refusing to take his calls, Monroe throws himself into his job, tackling life at the hospital with his usual energy and humour. Anna makes it clear that she has moved on, so Monroe tries to embrace his new single status, but is he ready to leave the past behind? When an ex-soldier is admitted with a blood clot in his brain, Monroe takes the controversial decision to avoid surgery. As he comes under increasing pressure to operate, will his 'wait and see' approach be the right one? Jenny Bremner is torn when she is asked to operate on an elderly lady for the second time. Will she break her own rule and let emotion get in the way of her clinical instincts? Monroe finds Shepherd's love life a welcome distraction from his own, but he is shocked when the identity of his friend's new woman is finally revealed. Springer tries to cover up the fact that he has mislaid a patient.

Medical drama series. Monroe's life plunges further into chaos as he discovers that civilised divorce is harder than he had ever imagined. As Anna starts a new life, Monroe is determined to show that he can move on too, but his attempts to enter the world of dating seem doomed to failure. At the hospital, Monroe is sure that surgery can help Brendan, a family man whose epileptic seizures have been getting worse. But Brendan believes that God is talking to him during his seizures, and is reluctant to give up these powerful religious experiences, even if it means his condition will deteriorate. Monroe tries to convince him to go ahead with the operation, but Brendan's teenage daughter Phoebe accuses Monroe of being too arrogant to understand her father's special closeness to God. Witney and Mullery are unnerved by Bremner's suspiciously good mood - but when Monroe reveals that he knows about her relationship with Shepherd, Bremner is incensed.

ITV's medical drama series continues. When registrar Sally Fortune collapses, Monroe is faced with the terrifying prospect of operating on a colleague. Fortune's condition is serious - she has an aneurysm in her brain which could burst at any moment, and one wrong move during surgery risks leaving her permanently brain-damaged. Monroe's thorny relationship with Bremner reaches a crisis point when she becomes involved in Fortune's treatment, and Shepherd finds himself torn between his best friend and his new girlfriend. Meanwhile, Witney has to contend with a patient who refuses to have her surgery cancelled and Springer learns that no patient is disposable. At home, Monroe claims that he is being mature by helping his wife to start a new life without him, but their son Nick is not convinced. Is Monroe finally ready to let go of the past, or is he giving up on his marriage too easily?

Final episode of the medical drama series. Monroe is finally forced to confront the painful truth about his past when a lively night shift at the hospital suddenly takes a darker turn. A 13-year-old girl is admitted following a road accident and Monroe knows that there is little chance of saving her - and that an operation could leave her severely brain-damaged. The girl's father begs him to operate and give her a chance to live - whatever the consequences. Can Monroe save her - and will he ever be able to let go of his own grief and make peace with his family? Shepherd is still smarting from his break-up with Bremner, but finds it impossible to avoid her at the hospital. When Monroe discovers that Shepherd is thinking about leaving, he begs Bremner to give his best friend a second chance - but Shepherd is not prepared for what Bremner has to tell him. Meanwhile, the competition between the trainees intensifies as the day of their assessments arrives.