After the events of `Strike Back: Legacy', Section 20, the secretive branch of the British Defence Intelligence service, was disbanded. After a brutal prison break results in the escape of one of the world's most brutally ambitious and notorious terrorists, Section 20 is reformed with a new team and a single-minded purpose. The unit embark on an international manhunt through Europe and the Middle East, uncovering deadly conspiracies which threaten to overwhelm them and change the course of humanity forever.