The series that follows the patients and staff at Royal Prince Alfred Hospital in Sydney. Actor James has been suffering from persistent headaches. An MRI scan of his brain reveals multiple aneurysms, which could burst at any time.

We catch up with Jolene, who has recently undergone marathon surgery to remove a recurrence of a rare type of cancer.

Forty-four-year-old mother Amy is confronted with a life-changing diagnosis of a rare abdominal cancer, only discovered by chance when trying for her second baby.

A 25-year-old adventurer and rock climber with lifelong liver disease needs a transplant or his devoted family will lose him within months.

Single mum Tracy faces a life-and-death battle with a rare and aggressive brain cancer. Also, meeting Kylie, the RPA coordinator revolutionising emergency stroke care.

When Kyle's first kidney transplant from an organ donated by his brother fails, he gets a second chance at life when his sister Jess offers to donate one of hers.