CIA hit-man Al Simmons's death causes him to seal a deal with the Devil so that he can return to his wife, Wanda; however, the Devil transforms him into hell spawn.

Peeved at the death of his three henchmen, mob boss Tony Twist sends a new trio to the alley. They soon return with a warning from Spawn: for Twist to stay away.

A hired cyborg named Overkill engages Spawn in battle in the alley, forcing Spawn to steal some of Al Simmons's old "tools of his trade" from a guarded CIA weapons compound.

Tony Twist sends an underling named Castellano to Rome to apologise for Overkill's death, while Wanda goes to the park to meet Max -- a private investigator.

A grenade-toting preacher holds a mute boy hostage, threatening to kill anyone who gets in his way. Later, Spawn is forced to intervene.

Spawn uncovers the truth about his identity as the kidnapping of Wanda's daughter edges him toward a showdown with Billy.