Andrew Fiscella

The BAU travels to Chicago to investigate a series of mass murders, after teenagers in a missing persons report become the main suspects.

A teenage girl is admitted to Princeton Plainsboro when a 200-year-old medicine jar found on an offshore shipwreck shatters in her palm. Her symptoms are linked to smallpox. Meanwhile, Wilson and Sam comfort a young chemo patient.

Frankie Jr. is brought in to help with a murder case involving a youth hockey league; Cailin asks to stay with Maura; Maura has trouble living with a teenager.

The family of a medical marijuana dispenser is held hostage, but the job of finding the kidnappers becomes harder after the best potential witness is killed by the dispenser's security guard.