In this Callie and Arizona centric episode, the couple takes a look into the problems that have contributed to their troubled marriage. At work, Callie immerses herself in the Veterans' project, and Arizona struggles to impress Dr. Herman. Meanwhile, Richard leans on Bailey for advice.
Maggie and Meredith disagree with Derek about the best way to approach a patient's case, which leads to a bigger argument between the couple. Meanwhile, Callie feels responsible when one of her veterans is pushed too far and one doctor's routine procedure results in a devastating diagnosis, on the winter finale.
Secrets about Amelia's past addictions come to light and cause problems for her at the hospital; Bailey oversees Jo's first solo surgery; and Arizona must make an executive decision in Dr. Herman's absence. Meanwhile the doctors spring into action when a couple arrives at the emergency room after escaping a fire.