Dr. William Masters runs a successful medical practice and conducts a secret study of human sexuality; a former nightclub singer proves to be an asset to Masters' work.

The complications following the presentation continue to ripple for Masters; Libby pushes Masters to get another job; Virginia fights off advances.

At the forefront of the Sexual Revolution, Masters and Johnson are about to publish their study, finally removing the shroud from the work that’s consumed them for the past decade. As they face the press for the first time, they flashback to a summer vacation of the year prior, where Virginia is faced with parenting struggles, Bill is finishing work on their book, and Libby is pulling herself out from beneath a deep depression.

Masters and Johnson try to find purpose with out each other; Libby is alone for the first time since her marriage.