Three years after the Bone Collector ended his career, Detective Lincoln Rhyme teams up with NYPD officer Amelia Sachs to investigate a series of murders that suggest the killer's return, and an unlikely team is born.

Lincoln and Amelia join forces to find a killer inspired by Greek mythology who is live-streaming murders; the Bone Collector prepares a terrifying gift to celebrate Lincoln's return to work with his new partner.

When a young woman from an insular Russian community who witnesses a murder comes to Lincoln and Amelia for help, the case takes a shocking turn when the mysterious murder is linked to a cold case; the Bone Collector's secret is discovered.

A bizarre murder at a university research site thrusts Amelia and Kate into the world of post-mortem forensics; Lincoln explores new possibilities with the help of Sellitto's friend.

The Bone Collector challenges Lincoln, Amelia and the team with a trifecta of victims across the city; as the team races to solve the clue trails before it's too late, Lincoln must come to terms with the Bone Collector's real target: his own ego.

Lincoln and the team hunt a serial killer who stages perfect murders by brilliantly framing suspects in what appear to be open-and-shut cases; the hunt hits home when one of Lincoln's closest friends is accused.