Powerpuff Girls Z is a 2006 Japanese magical girl anime series directed by Megumu Ishiguro, based on the American animated television series The Powerpuff Girls. The anime was co-produced by Cartoon Network Japan and Aniplex and was animated by Toei Animation. The series featured character designs by Miho Shimogasa, who was the character designer of Cutie Honey Flash and Ultra Maniac and one of the animation directors of Sailor Moon.