When the actions of Jason Bourne spark a fire that threatens to burn down decades of research across a number of secret intelligence agencies, Eric Byer (Edward Norton), the man who built the programs, decides he must sacrifice one of them: Outcome. Aaron Cross (Jeremy Renner), one of Outcome's six agents, and research scientist Marta Shearing (Rachel Weisz) go on the run when Byer targets them for termination. But Cross proves to be a far deadlier target than Byer realizes.