Inspired by the oldest public hospital in America, this unique medical drama follows the brilliant and charming Dr. Max Goodwin, the institution's newest medical director who sets out to tear up the bureaucracy and provide exceptional care.

Max navigates his diagnosis while Dr. Sharpe encourages him to make a plan. Meanwhile, Dr. Bloom encourages Reynolds to take a chance and Dr. Kapoor and Iggy work together to help a child.

Reynolds begins to build his department as Dr. Sharpe battles scepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.

When Max volunteers New Amsterdam to take over for a short-staffed hospital nearby, things get chaotic quickly. Iggy has a crisis of conscience after receiving the news that funding for a garden has been granted and an eager resident learns a secret about Dr. Bloom.

A journalist visits New Amsterdam to shadow Max and learn about the hospital. Bloom and Reynolds have a major disagreement after she makes a call against protocol and Kapoor deals with issues from his past.

The pressure is on as Max takes on his first annual fundraising gala at the hospital and emotions are high as some of the doctor's families join them for the event. Meanwhile, Kapoor and Dr. Sharpe work together to find out what is making a father and son duo so sick.