Based on the popular video game, Milla Jovovich and Michelle Rodriguez star as the leaders of a commando team who must break into "the hive," a vast underground genetics laboratory operated by the powerful Umbrella Corporation. There, a deadly virus has been unleashed, killing the lab's personnel and resurrecting them as the evil Un-dead. The team has just three hours to shut down the lab's supercomputer and close the facility before the virus threatens to overrun the Earth.