Christopher Duntsch begins operating at a Dallas hospital where he leaves two patients seriously maimed and another dead; Dr. Henderson and Dr. Kirby investigate whether Duntsch's surgical abilities amount to incompetence or murder.

Henderson and Kirby discover a history of Duntsch's medical misadventures and set out to strip him of his medical license; Duntsch obsessively struggles to make the football team at Colorado State before moving home and pursuing a career in medicine.

Duntsch studies under the tutelage of a renowned neurosurgeon while seeking a patent for his stem cell research; Henderson and Kirby uncover a series of disturbing revelations about the medical system's accountability in Duntsch's time in Texas.

Henderson and Kirby crash a function in Duntsch's honor and wind up confronting the systemic failure at the heart of his reign of terror; Duntsch moves to Texas, sets up his private practice and is recruited by one of the nation's premier hospitals.

Duntsch begins his tenure operating in Dallas and the medical misadventures stack up immediately; Henderson and Kirby get support from ADA Michelle Shughart in leveraging the legal system to stop Duntsch before he can do any more damage.

Duntsch attempts to fix a disastrous surgery performed on a friend while the administration at Baylor suspects that drugs may be influencing his outcomes; Henderson and Kirby lend Shughart their expertise as she builds her case against Duntsch.