M.O.D.O.K. is forced to sell his evil organization, AIM, to the tech company, GRUMBL; as M.O.D.O.K. struggles to regain control of AIM, he risks losing his family.

M.O.D.O.K. drags along his kids, Melissa and Lou, to a GRUMBL leadership conference; once there, he accidentally unleashes a hedonistic alien menace on the conference while trying to prove his leadership skills to his bosses and children.

M.O.D.O.K. is turned away by his world conquering peers and forced to slum it with some blue collar street villains; he intends to use them for his own gains, but a wild night out on the town leads M.O.D.O.K. to something more valuable.

M.O.D.O.K. and Monica reluctantly team up to overthrow GRUMBL's control of AIM; their history threatens their mutual goals as they work through their grievances the only way they know how.

M.O.D.O.K. struggles to "normalize" his weird son Lou's Bar-Mitzvah planning; Lou flees to Asgard where he and M.O.D.O.K. find themselves on opposing sides of a mythological war that threatens to split the realm in two.