S1, E9: An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting, and the chief reluctantly confides to Derek about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; just as Meredith and Derek grow more intimate, a bombshell is dropped.