Road Trip centers on Ithaca University student Barry (Tom Green) and his friends. Trouble begins when Barry's friend Josh (Seann William Scott) cheats on his girlfriend (Rachel Blanchard) with the girl he really likes, Beth (Amy Smart). Not only is his video camera accidentally left on but his friend accidentally mails it to his girlfriend in Austin. Barry remains behind on campus while Josh and three friends set off on an 1,800 mile epic road trip on which they blow up their car, constantly run out of money and regain it in various ways, meet all sorts of crazy people, and learn their respective lessons about standing up to your parents, getting girls, friendship, etc.