T-Bag goes postal to track down a missing Mrs. Hollander. Sucre's escape plane faces deadly turbulence. Bellick has the tables turned on him upon his return to Fox River Penitentiary. Michael and Lincoln are taken into custody to be transported back to Fox River, forcing Mahone and Kellerman to take drastic measures to ensure that the brothers make it to the prison morgue instead of their cells. And a surprising ally changes the game for everyone.
Jason Bly, a federal agent who has a knack for giving Michael trouble, returns to Miami to force Michael to hand over some blackmail materials. When they get trapped in a bank robbery together, however, the two enemies must work together to survive.
Bull finds himself on the opposite side of voir dire, when he serves jury duty while simultaneously mounting a defense for a woman on trial for killing her daughter's murderer.
Buddy Garrity (Brad Leland) has a run-in with the law and is forced to come clean about his financial troubles to Lyla (Minka Kelly). Landry (Jesse Plemons) agrees to tutor Tyra (Adrianne Palicki) for the SATs, but he quickly reaches a breaking point. J.D. (guest star Jeremy Sumpter) meets a girl at school but his dad Joe (D.W. Moffett) worries that his son is losing his focus on football. Kyle Chandler, Connie Britton, Taylor Kitsch, Zach Gilford and Aimee Teegarden also star.
A teenage girl's death is tied to the illegal sale of prescription drugs; Henry reconnects with a former flame; Cady goes back home.
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