Peter’s sister, Karen, decides to come for Thanksgiving and bullies Peter the same way Meg treats him. While Meg is at first amused, she later feels badly and decides to help Peter train to defeat his sister in a wrestling match. Meanwhile, to avoid overeating on Thanksgiving, Stewie and Brian decide to go on a cleanse, which Stewie takes one step too far.
Dorothy is hesitant about having foot surgery just as she was scheduled to tap dance with Blanche and Rose at a dance recital.
Roseanne finds herself upset over Bev moving into a retirement community, meanwhile Nancy announces she is a lesbian.
It's a magical "freaky friday" when Alex switches places with her mother to allow her to experience the thrills of the Quinceanera that she never had.
Members of the Tanner family are thrilled when they are chosen to appear in a local promotion at Danny's TV station. But their enthusiasm subsides when they discover show business is not as glamorous as they had thought.
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