Dr. Shaun Murphy has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Jared Kalu has to learn to accept his limitations as a surgeon.
During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.
Shaun and Claire devise an experimental procedure capable of saving a young groom's leg and life, but the patient's loved ones must learn to work together. Meanwhile, Jared struggles to connect with a patient whose scars may prove too deep to overcome.
Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez's personal life could be affecting his work and, ultimately, his patients lives.
As Shaun and Jared debate how to treat a twelve-year-old transgender girl’s cancer, Claire and a competitive new resident must work together to save a single father from a drug-resistant super bug.