McCall races to find a woman kidnapped by a serial killer whose past crimes went undetected because the victims were from marginalized communities. Also, trouble arises for McCall when her vigilante activity puts her on Manhattan District Attorney Avery Grafton's (Jennifer Ferrin) radar.
Frank is blindsided when Mayor Chase bypasses him with a request for Jamie to head his security detail. Also, Danny and Baez investigate the murder of a wealthy college student.
When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy. Meanwhile, Sharpe and Kapoor work together to mend fences between two feuding sisters.