When one teenager is found murdered and her best friend is abducted in Chula Vista, California, the BAU must profile the killer and find him before he kills the other teen.
Caught in an impossible scenario, Reid must square off with an old nemesis, and Derek Morgan (guest star Shemar Moore) comes to the team with a lead that might help catch Mr. Scratch, the elusive fugitive that has been tormenting the team all season.
When Reid fears his mother has been abducted, he asks the BAU to investigate while he's stuck in prison.
When several federal government employees, including a close friend of Walker's, succumb to symptoms of a heart attack, the BAU investigates. Also, Reid anxiously awaits his trial date. Jane Lynch guest stars.
Mike accompanies Sue on a college tour weekend, and Frankie abandons Brick with a school project and a revolving door of babysitters while she goes to see Axl play in his first college football game.