Uncle Junior's associate Mikey Palmice stirs things up by making Junior think Tony wants to be next in line for boss. Meanwhile, Tony, Paulie and Silvio deal with Hasidic family problems.
Jackie Aprile's health worsens, forcing Tony to make a tough decision. Meanwhile, Anthony Jr. learns the true nature of his father's job in 'waste management.' Also, Tony hires sleazy police lieutenant Vin Makazian to investigate Dr. Melfi's background.
During a trip to Maine for Meadow's college interviews, Tony sees a man he believes is a relocated mob snitch. Back at home, Carmela receives comfort from Father Phil.
At Tony's suggestion, Junior is made acting boss after Jackie dies. In therapy, Tony surprises Dr. Melfi with a surprise admission. Carmela and Irina (Tony's mistress) both suffer as Tony's libido takes a nosedive.
Season Two premiere. In the aftermath of the federal crackdown, Junior's in jail, Melfi refuses to see Tony, Christopher's expanding into new business ventures, Pussy is still missing...and Tony's adjusting to life as the new boss. To complicate matters even more, Tony's long-lost, free-spirited sister Janice arrives to take care of a hospitalized Livia.
