Saige Ryan Campbell

Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House's games and becomes involved in a power struggle as he and the team take on the case of a Special Education teacher who collapsed after spitting up blood in the middle of class. As House tests Cameron's tolerance for his extreme measures, the patient continues to fall ill and House insists the teacher's seemingly inherent goodness is actually a pathology. Meanwhile, Foreman must make a critical decision regarding Thirteen's participation in the Huntington's drug trial.

A casting change puts 'Medellin' back on the table for Vince. Ari and producer Nick Rubenstein must broker the deal between Amanda and the studio by day's end, but because it's Yom Kippur they can't use the most important tools of their trade (cell phones) until after sundown. Eric suspects that Vince and Amanda's relationship is sabotaging the deal. At the races, Drama saves an injured horse from the glue factory.

The eldest daughter of a family involved in a car crash must make a difficult decision; Teddy asks Cristina to help with an O.R. patient; Lexie works with Mark's new girlfriend during a surgery.

Nick helps Hugh Williams, a 33 year old retarded man with anger issues (whom Nick grew up), save his somewhat ill dog from being put to sleep at the city pound after the dog bites a police officer.

Jack and the team search for Joe Gibson (Jerry O'Connell - Kangaroo Jack, Mission to Mars), who disappeared after a chase and gunfight with unidentified figures. But as they learn more about Joe, who worked as a public defender, the squad members become convinced that he is a paranoid schizophrenic and poses a danger to himself and others. Jack's training in psychology becomes crucial as they track him down through a variety of associates, many of whom are worried about Joe's sanity. And when a little girl is reportedly abducted by the delusional Joe, the investigation becomes even more intricate and urgent.