While Magnum and Higgins reunite and work the case of a construction worker's tragic death, TC and Shammy get skyjacked by a pair of drug runners posing as tourists.
The doctors find their own lives in danger when they arrive at the scene of a massive multi-vehicle accident on a highway covered in thick fog. Also, Jesse's confidence is shaken following his heart attack, while Carla's (Shiri Appleby) condition becomes critical.
As the doctors treat patients from the chaotic multi-vehicle accident, a love triangle begins to build between Mario, Angus and Heather. Also, when Malaya learns that Carla is at the hospital, she goes against Carla's wishes and stays by her side during the delivery of her baby. Shiri Appleby guest stars.
A dying sheriff’s deputy leaves TC (Eoin Christopher Macken) facing giving him a heart transplant for the second time. Landry’s (Daniella Alonso) child abuse investigation produces a startling diagnosis.
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