When a deadly epidemic breaks out in Atlanta, a vast urban quarantine is quickly enforced, leaving those stuck on the inside to fight for their lives while local and federal officials race to find a cure. Trying to keep the peace is police officer Lex Carnahan, whose job becomes even harder when he learns that his longtime girlfriend and best friend are trapped within the cordoned area. On the outside, Dr. Sabine Lommers is leading the government efforts to contain the outbreak and has asked for Lex’s help in enforcing the cordon — which grows increasingly difficult as the public trust deteriorates. Torn apart from their loved ones, the survivors trapped within the cordon not only face fatal infection, but also isolation, fear and the disintegration of society around them. But as they begin to gain each other’s trust, hope remains, and on either side of the cordon, unlikely heroes will rise.