Andy Richter ("Late Night with Conan O'Brien") re-teams with Conan O'Brien (series co-creator and executive producer) in this comedy as he portrays Andy Barker, an earnest, hard-working CPA who has succeeded at everything -- until his new accounting business fails to take off. But when he's mistaken for Lew Staziak (Harve Presnell, "Fargo"), the retired private detective who used to occupy his storefront office, Andy embraces the twist of fate and dives into his double life. Andy's relentlessly supportive wife Jen (Clea Lewis, "Ellen") isn't sold on this risky new venture, that is, until she notices a sudden boost in Andy's self-confidence. Andy's fellow strip-mall neighbors -- Simon (Tony Hale, "Arrested Development") and Wally (Marshall Manesh, "Will & Grace") join him in the dicey investigation. In the pilot episode, Andy Barker, begins his double life as a private investigator when he's hired to solve a case involving a missing husband and the Russian mafia. This comedy series was created by O'Brien and former "Late Night" head writer Jonathan Groff ("Ed"), who executive-produce the series with Jeff Ross and David Kissinger. "Andy Barker, P.I." is from NBC Universal Television Studio and Conaco. The pilot was directed by Jason Ensler ("The West Wing").

When a client of Andy's (Andy Richter) drops dead while playing golf, his wife hires Andy to find the murderer. Andy is shocked to discover that his overweight, crass and rude client had been the object of desire for many people. Simon (Tony Hale), Wally (Marshall Manesh), Lew (Harve Presnell) and Andy's wife Jen (Clea Lewis) lend him a hand with the case. Meanwhile, Simon develops a crush on Andy's assistant.

When Wally, (Marshall Manesh) owner of the falafel restaurant is being scammed and forced to serve tainted chicken, Andy (Andy Richter) and Simon (Tony Hale) begin to investigate the chicken processing plant. Lew (Harve Presnell) gives Andy and Simon important information about the chicken industry. Meanwhile, in an attempt to impress her new coworkers, Jenny (Clea Lewis) hosts a barbecue at the house but Andy crashes Jenny's party when he suspects the chicken she is serving could be tainted.

Tax day--Traci Lords "First Wave" and Frank Santorelli "The Sopranos" guest star--When Lew (Harve Presnell) forgets to warn Andy (Andy Richter) about an upcoming case, Andy's laptop is stolen before he is able to send in his father-in-law's tax return. The search is on as Andy races against the clock to file the return and expose a credit card scam involving Loretta Crispin (guest star, Traci Lords “First Wave”). Simon (Tony Hale) and Wally (Marshall Manesh) help Andy investigate the suspects. Clea Lewis also stars.

Sleep deprived--Lew (Harve Presnell) enlists Andy’s (Andy Richter) help to investigate a dishonest doctor and his involvement with several of his attractive married patients. Meanwhile, Andy and Jenny (Clea Lewis) loose sleep when their daughter misplaces her favorite toy. Andy and Simon (Tony Hale) go on a quest to investigate the doctor and locate the missing baby toy. Marshall Manesh also stars.

Long lost love--Amy Sedaris 'Strangers With Candy" and Ed Asner “Mary Tyler Moore" guest star--Andy (Andy Richter) tries to prove that Lew's (Harve Presnell) old flame, Rita Spaulding (guest star, Amy Sedaris "Strangers with Candy") is innocent after she has spent the past 40 years in prison. While trying to solve the crime, Andy runs up against Lew's corrupt former LAPD partner, Mickey Wheeler (guest star, Ed Asner "Mary Tyler Moore"). Simon (Tony Hale) helps Andy gather evidence he needs to solve the 40 year old crime. Clea Lewis and Marshall Manesh also star.