Up until 6 years ago, 52-year-old Paul was a normal dad doing a nine-to-five; now, Paul has a severe case of Tourette's Syndrome; despite the extreme nature of his condition, Paul is desperate to succeed at work once again.

Tom is 27 and has an extreme form of Tourette's Syndrome and he has found it impossible to find a career he can succeed in.

Ellie lead a perfectly normal life until, out of the blue, she started yelling for marshmallows in a supermarket; Ellie developed full-blown Tourette's and was forced to leave her job as a youth worker; she is now desperate to find a job.

Andy was a successful businessman, but six years ago he suffered a stroke during a routine operation; Andy has applied for over 3,000 jobs and has only ever received one interview.

Nicola was diagnosed with cerebral palsy at the age of two; she has a first-class honors degree in multimedia journalism, but despite hundreds of applications she has never had a permanent job.

Thirty year old Dubliner Kerie has been blind all her life; two years ago, after struggling to find work in Ireland, she took the brave step of leaving her family home and moving to the U.K. on her own.