Witness the journey of Tom and Jodi, both 37 from Houston, Texas, and learn more about why they are heavy and how they can reverse their lifestyles through health, nutrition and exercise methods. Tom was the star of his high school football team, but after he dropped out, he fell into a world of depression and overeating. Now, at 37 years old and 638 pounds, Tom suffers from a myriad of issues. He can barely walk to the car, let alone work a job or start a family. He is desperate to get his life back before he loses it permanently. Having recently suffered a stroke, Jodi, 36 years old and 363 pounds, is at a critical juncture with her health. Her husband must take care of the family because she can't keep up with their two children. Now, he's reached the end of his rope and Jodi must change for the better.

At 45-years-old and weighing 446 pounds, Ronnie is engaged to be married to the love of his life, Cara. Unfortunately, Ronnie's weight is keeping them from realizing their dream of the perfect beach wedding. Tired of waiting for his life to begin again, Ronnie is ready to take off the weight and become the husband Cara deserves. Debbie is 44-years-old and weighs 401 pounds. She never has had a date, or a full time job, and is still financially dependant on her parents. Sick of living on the sidelines, just watching her life go by, she is ready to make the change. At her age, she realizes--it's now or never.

Jill wants nothing in the world more than to have a baby, but at 35 years old and 305 pounds, her doctor told her she has a hundred pounds to lose before she can become pregnant. Will Jill be able to reach her goal to be a mom, or will her history of being a closet eater come back to haunt her? Johnny, at 443 pounds, has spent most of the 19 years of his life using food as a comfort. Abandoned by his biological mother at age three, Johnny has struggled with his weight ever since. Now Johnny is ready to let go of the anger, and get a fresh start in life.

Bill, 52 years old and 443 pounds, is a former college football star with two national championships under his belt who at one time had it all, but lost his job, his family, and his waistline because of drug addiction. He's since kicked his addiction to pain pills, but now it's time to see if he can beat his other addiction--food. Julia, 25 years old and 255 pounds, has spent her entire life having her weight compared to her skinnier twin sister, so when her boyfriend broke up with her because her weight made her no longer attractive to him, she reached wits end. Now Julia is ready to show everyone that, underneath all the extra layers, there is a strong confident woman ready to take on the world.